📝 SummarXiv

Abstract

Magnetic hyperthermia with metallic nanoparticles is a therapeutic strategy that relies on heating cancer cells to levels sufficient to damage or destroy them. After injection, the nanoparticles accumulate in tumor tissues, where they transfer energy from the applied time-dependent magnetic field to the surrounding medium, thereby increasing the local temperature. This heating effect can be spatially focused (superlocalized) by combining AC and DC magnetic fields. Heat generation arises either from the rotation of the particle or from the rotation of its magnetic moment. The theoretical framework is provided by the Martsenyuk-Raikher-Shliomis (MRSh) equation for the former and the stochastic Landau-Lifshitz-Gilbert (sLLG) equation for the latter. However, by using the concept of magnetic and ordinary viscosity, the results of these approaches can be directly compared, which is our goal in this work, with special emphasis on their ability to achieve spatial localization. On the basis of this comparison, we propose the use of perpendicular AC and DC magnetic fields for image-guided thermal therapy with magnetic particle imaging.