📝 SummarXiv

Abstract

Understanding how oxygen supply shapes neuronal excitability is crucial for explaining brain function in pathological scenarios, such as ischemia. This condition is caused by a reduced blood supply, leading to oxygen and other metabolites deprivation; this energy deficit impairs ionic pumps and causes cellular swelling. In this work, this phenomenon is modeled through a volumetric variation law that links cell swelling to local oxygen concentration and the percentage of blood flow reduction. The swelling law ties volume changes to local oxygen and the degree of blood-flow depression, providing a simple pathway from hypoxia to tortuosity-driven transport impairment. To study the interplay between oxygen supply and excitability in brain tissue, we employ a monodomain model coupled with specific neuronal ionic and metabolic models that characterize ion and metabolite concentration dynamics. From a numerical point of view, suitable space- and time-adaptive schemes are employed to capture the sharp and fast-traveling wavefronts representing action potentials more accurately. This multiscale model is discretized in space with the high-order p-adaptive discontinuous Galerkin method on polygonal and polyhedral grids (PolyDG) and integrated in time with a Crank-Nicolson scheme. We numerically investigate different pathological scenarios on a two-dimensional, idealized square domain discretized with a polygonal grid, analyzing how subclinical and severe ischemia can affect brain electrophysiology and metabolic concentrations.