A Unified AI Approach for Continuous Monitoring of Human Health and Diseases from Intensive Care Unit to Home with Physiological Foundation Models (UNIPHY+)
Minxiao Wang, Saurabh Kataria, Juntong Ni, Timothy G. Buchman, Jocelyn Grunwell, Mark Mai, Wei Jin, Matthew Clark, Stephanie Brown, Michael Fundora, Puneet Sharma, Tony Pan, Sam Khan, Timothy Ruchti, Naveen Muthu, Kevin Maher, Sivasubramanium V Bhavani, Xiao Hu
公開日: 2025/9/19
Abstract
We present UNIPHY+, a unified physiological foundation model (physioFM) framework designed to enable continuous human health and diseases monitoring across care settings using ubiquitously obtainable physiological data. We propose novel strategies for incorporating contextual information during pretraining, fine-tuning, and lightweight model personalization via multi-modal learning, feature fusion-tuning, and knowledge distillation. We advocate testing UNIPHY+ with a broad set of use cases from intensive care to ambulatory monitoring in order to demonstrate that UNIPHY+ can empower generalizable, scalable, and personalized physiological AI to support both clinical decision-making and long-term health monitoring.