📝 SummarXiv

Abstract

Confirming Turing's theory of morphogens in developmental processes is challenging, and synthetic biology has opened new avenues for testing Turing's predictions. Synthetic mammalian pattern formation has been recently achieved through a reaction-diffusion system based on the short-range activator (Nodal) and the long-range inhibitor (Lefty) topology, where a single function regulates both morphogens. In this paper, we investigate the emergence of Turing patterns in the synthetic Nodal-Lefty system. First, we prove the existence of a global solution and derive conditions for Turing instability through linear stability analysis. Subsequently, we examine the behavior of the system near the bifurcation threshold, employing weakly nonlinear analysis, and using multiple time scales, we derive the amplitude equations for supercritical and subcritical cases. The results demonstrate the ability of the system to support various patterns, with the subcritical Turing instability playing a crucial role in the formation of dissipative structures observed experimentally.