📝 SummarXiv

Abstract

This paper addresses the Longest Filled Common Subsequence (LFCS) problem, a challenging NP-hard problem with applications in bioinformatics, including gene mutation prediction and genomic data reconstruction. Existing approaches, including exact, metaheuristic, and approximation algorithms, have primarily been evaluated on small-sized instances, which offer limited insights into their scalability. In this work, we introduce a new benchmark dataset with significantly larger instances and demonstrate that existing datasets lack the discriminative power needed to meaningfully assess algorithm performance at scale. To solve large instances efficiently, we utilize an adaptive Construct, Merge, Solve, Adapt (CMSA) framework that iteratively generates promising subproblems via component-based construction and refines them using feedback from prior iterations. Subproblems are solved using an external black-box solver. Extensive experiments on both standard and newly introduced benchmarks show that the proposed adaptive CMSA achieves state-of-the-art performance, outperforming five leading methods. Notably, on 1,510 problem instances with known optimal solutions, our approach solves 1,486 of them -- achieving over 99.9% optimal solution quality and demonstrating exceptional scalability. We additionally propose a novel application of LFCS for song identification from degraded audio excerpts as an engineering contribution, using real-world energy-profile instances from popular music. Finally, we conducted an empirical explainability analysis to identify critical feature combinations influencing algorithm performance, i.e., the key problem features contributing to success or failure of the approaches across different instance types are revealed.