An overview of PBPK and PopPK Models: Applications to Radiopharmaceutical Therapies for Analysis and Personalization
Deni Hardiansyah, Bisma Baron Patrianesha, Kuangyu Shi, Babak Saboury, Arman Rahmim, Gerhard Glatting
公開日: 2025/9/11
Abstract
This review discusses the current applications, advantages, and limitations of PBPK and PopPK models in radiopharmaceutical therapy (RPT). PBPK models simulate radiopharmaceutical kinetics by integrating prior physiological and drug parameter information, whereas PopPK models leverage population data to enhance individual dose estimation accuracy. Future directions include developing hybrid models, incorporating artificial intelligence, and establishing regulatory guidelines to promote their clinical adoption. Ultimately, these modeling strategies aim to enable precise, personalized RPT dosing, thereby improving therapeutic outcomes and safety.