Molecular-Size Control of Properties of Therapeutic Nano-Paper Allows for Selective Drug Storage in Small Doses
Elisabeth Erbes, Naireeta Biswas, Calvin J. Gavilett, Matthias Schwartzkopf, Krishnayan Basuroy, Qing Chen, Andrei Chumakov, Susann Frenzke, Marc Gensch, Korneliya Goordeyeva, Patrycja Kielb, Sonja Kirchner, Volker Körstgens, Peter Müller-Buschbaum, Henrike M. Müller-Werkmeister, Jan Rubeck, Sreevidya Thekku Veedu, Jose de Jesus Velazquez-Garcia, Vivian Waclawek, Daniel Söderberg, Stephan V. Roth, Simone Techert
公開日: 2025/9/9
Abstract
A novel concept of nano-scaled interwoven templates for drug delivery with alternating hydro- and lipophilicity properties is introduced. They are built from cellulose and peptide hydrogel in tandem, and characterized by a nano-stacked interwoven design, thus enabling for tuning the lipophilicity in the mesh nano-domains in which drug candidates of complementary lipophilicities can be embedded. This allows for low-dose-controlled consumption and therapeutic applications. Time-resolved and in-situ grazing incidence X-ray scattering studies confirm the design of the therapeutic nano-paper and create conditions suitable for the drug storage of complementary properties. The molecular design has the potential of a locally controlled, site-specific drug release on a beyond-nanomolar scale. Generalized, the design may contribute to facile developments of personalized medicine.